【题目】Because he was the only graduate of the factory, the boss asked him to _______ the business for some time.
A.in the charge of
B.in charge of
C.take charge of
D.take the charge of

【答案】C
【解析】根据句意：因为他是厂里唯一的大学毕业生，老板让他负责一段时间厂里的事务。根据ask sb. to do sth.这一固定用法可排除A、B两项；take charge of “负责”，为固定短语，符合语境。