【题目】________ all her effort, she failed to reach her aim.
A.Because of
B.Instead of
C.In spite of
D.Together with

【答案】C
【解析】考查词组。“in spite of+名词”在句中起让步状语从句的作用，意为“尽管，不管”。句意：尽管她尽了最大努力，但没有实现目标。instead of "而不是"，together with"和...一起"。故选C。